Peroxisome Proliferator Activator α Agonist Clofibrate Induces Pexophagy in Coconut Oil-Based High-Fat Diet-Fed Rats
Peroxisome Proliferator Activator α Agonist Clofibrate Induces Pexophagy in Coconut Oil-Based High-Fat Diet-Fed Rats Introduction In the realm of nutritional science and metabolic research, understanding the mechanisms of cellular processes such as pexophagy is crucial. Pexophagy, the selective degradation of peroxisomes through autophagy, plays a vital role in maintaining cellular homeostasis. This blog explores the latest findings on how clofibrate, a well-known PPARα agonist, influences pexophagy in rats subjected to a high-fat diet (HFD) based on coconut oil. These insights potentially pave the way for novel therapeutic strategies targeting metabolic disorders. Methodology The study meticulously divided rats into distinct groups to evaluate the impact of a coconut oil-based HFD. One group received clofibrate, allowing for a comparative analysis of pexophagy markers between treated and untreated subjects. The selected markers, including NBR1, p62, and LAMP2, provided a comprehensive...